Research activity

• Analysis of oligosaccharide structures of stomach mucins (especially MUC 1) and evaluation of interactions between these structures and Helicobacter pylori adhesins
• Evaluation of the influence of transmembrane mucin MUC 1 on adhesive properties of cancer tissues 
• Evaluation of molecular mechanisms of osteogenesis imperfecta pathogenesis
• Analysis of degradation products of the cartilaginous tissue in joints diseases

Laboratory techniques

• PCR
• HPLC
• Spectroscopy UV/VIS
• Immunoenzymatic techniques (ELISA, Western blot)

• Electrophoretic techniques

Publications

• Aleksandra Auguściak-Dumna , Joanna Witecka, Aleksander L. Sieroń, Magdalena Janeczko, Jacek J. Pietrzyk, Karolina Ochman, Anna Galicka, Maria Borszewska-Kornacka, Jacek Pilch, Elżbieta Jakubowska-Pietkiewicz. Mutations in the COL1A1 and COL1A2 genes associated with osteogenesis imperfecta (OI) types I or III. Acta Biochimica Polonica 2018 : 65, 1, 79-86.
• Iwona Radziejewska, Katarzyna Supruniuk,  Jolanta Nazaruk, Ewa Karna, Bożena Popławska, Anna Bielawska, Anna Galicka. Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line. Biomedicine & Pharmacotherapy 2018, 107, 397-407.
• Iwona Radziejewska, Małgorzata Borzym-Kluczyk, Katarzyna Leszczyńska. Lotus tetragonolobus, Ulex europaeus, Maackia amurensis and Arachis hypogaea (peanut) lectins influence the binding of Helicobacter pylori to gastric carbohydrates. Advances in Clinical and Experimental Medicine, 2018, 27(6), 807-811
• Iwona Radziejewska, Edyta Andrulewicz,  Małgorzata Borzym-Kluczyk,  Joanna Wosek, Łukasz Szoka, Anna Bielawska and Anna Galicka. New findings of the effect of Wisteria floribunda lectin on gastric cancer cells. Acta Poloniae Pharmaceutica-Drug Research 2018, 75, 413-421.

•  Andrulewicz-Botulińska E. S.D., Wiśniewska R., Brzóska M.M., Rogalska J., Galicka A. Beneficial impact of zinc supplementation on the collagen in the bone tissue of cadmium-exposed rats. Journal of Applied Toxicology 2018, 12 pp.

• Iwona Radziejewska, Małgorzata Borzym-Kluczyk, Katarzyna Leszczyńska, Joanna Wosek, Anna Bielawska. Lotus tetragonolobus and Maackia amurensis lectins influence phospho-IκBα, IL-8, Lewis b and H type 1 glycoforms levels in H. pylori infected CRL-1739 gastric cancer cells. Advances in Medical Sciences, 2018, 63, 205-211.

• Andrea Baier , Jolanta Nazaruk , Anna Galicka, Ryszard Szyszka. Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms: effect of the regulatory subunit. Molecular and Cellular Biochemistry, 2017, 8 pp.
• Natalia Majewska, Ilona Zaręba, Arkadiusz Surażyński, Anna Galicka. Methylparaben-induced decrease in collagen production and viability of cultured human dermal fibroblasts. Journal of Applied Toxicology, 2017, DOI 10.1002/jat.3466
• Andrea Baier, Anna Galicka, Jolanta Nazaruk, Ryszard Szyszka. Selected flavonoid compounds as promising inhibitors of protein kinase CK2alpha and CK2alpha`, the catalytic subunits of CK2. Phytochemistry, 2017: 136, s. 39-45.
• Michał Karpiński, Anna Galicka, Robert Milewski, Janusz Popko, Vladimir Badmaev,  Sidney J.Stohs. Association between vitamin D receptor polymorphism and serum vitamin D levels in children with low-energy fractures. Journal of the American College of Nutrition, 2017, 8 pp.
• Gindzieńska-Sieśkiewicz E, Radziejewska I, Domysławska I, Klimiuk A, Sulik A, Rojewska J,  Gabryel-Porowska H, Sierakowski S. Changes of glycosylation of IgG in rheumatoid arthritis patients treated with methotrexate. Advances in Medical Sciences 2016 : 61, 1, s. 193-197.
• Anna Jakubiuk-Tomaszuk, Wojciech Sobaniec, Małgorzata Rusak, Elżbieta Poskrobko, Agata Nędzi [S.D], Beata Olchowik, Anna Galicka.  Decrease of interleukin (IL)17A gene expression in leucocytes and in the amount of IL-17A protein in CD4+ T cells in children with Down Syndrome.  Pharmacological Reports 2015, 67, 6, 1130-1134
• Gornowicz A [S.D], Bielawska A, Czarnomysy R, Gabryel-Porowska H,  Muszyńska A, Bielawski K. The combined treatment with novel platinum (II) complex and anti-MUC1 increases apoptotic response in MDA-MB-231 breast cancer cells. Mol Cell Biochem 2015, 408 (1-2), 103-113.
• Kuroczycka-Saniutycz E, Porowski T, Protas P, Pszczółkowska M [S.D], Porowska H,  Kirejczyk JK, Wasilewska A. Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis? Pediatr Nephrol 2015, 30 (5), 797-803.
• Kirejczyk JK, Korzeniecka-Kozerska A, Baran M, Porowska H, Porowski T,  Wasilewska A. Dyslipidemia in overweight children and adolescents is associated with an increased risk of kidney stones. Acta Paediatr 2015, 104, e407-e413.
• Gornowicz A [S.D], Kałuża Z, Bielawska A, Gabryel-Porowska H, Czarnomysy R, Bielawski K. Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells. Mol Cell Biochem 2014, 392 (1-2), 161-174.
• Galicka A, Krętowski R, Nazaruk J, Cechowska-Pasko M Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts. M.Mol Cell Biochem. 2014, 394(1-2):217-24
• Nazaruk J, Galicka A. The influence of selected flavonoids from the leaves of cirsium palustre (L.) scop. on collagen expression in human skin fibroblasts. Phytotherapy Research 2014, s. 1-6
• Gabryel-Porowska H., Gornowicz A., Bielawska A., Wójcicka A., Maciorkowska E., Grabowska S.Z., Bielawski K. Mucin levels in saliva of adolescents with dental caries. Med Sci Monit 2014, 20, 72-77.
• Radziejewska I, Leszczyńska K., Borzym-Kluczyk M. Influence of monoclonal anti-Lewis b,anti-H type1, and anti-sialyl Lewis x antibodies on binding of Helicobacter pylori to MUC1 mucin. Mol Cell Biochem 2014, 385, 249-255.
• Radziejewska I, Borzym-Kluczyk M., Leszczyńska K. Are Lewis b and H type1 on Helicobacter pylori involved in binding of bacteria to MUC1 mucin? Adv Clin Exp Med 2013, 22, 3, 347-353.
• Galicka A. Mutacje genów niekolagenowych we wrodzonej łamliwości kości-znaczenie produktów tych genów w biosyntezie kolagenu i patogenezie choroby. Postepy Hig Med Dosw 2012, 66, 359-371
• Radziejewska I. Rola mucyn żołądkowych w oddziaływaniach z Helicobacter pylori. Postepy Hig Med Dosw  2012; 66: 60-66
• Radziejewska I, Borzym-Kluczyk M, Namiot Z, Stefańska E. Glycosylation of mucins present in gastric juice: the effect of Helicobacter pylori eradication treatment. Clin Exp Med 2011, 11, 81-88.