Research activity

• Role of the ubiquitin-proteasom system in physiology and pathology
• Role of conidia fungi in natural environment
• Influence of physico-chemical parameters of water on mikoflora composition

Laboratory techniques:

• spectroscopic techniques:
  • spectrofluorimetry
• immunochemic techniques:
  • electrophoresis with immunoblot
  • ELISA
• microscopic techniques:
  • fluorescence microscopy
  • optical microskopy
• farmings conidial fungi

Publications:

• Krętowski R., Borzym-Kluczyk M., Stypułkowska A., Brańska-Januszewska J., Ostrowska H., Cechowska-Pasko M.: Low glucose dependent decrease of apoptosis and induction of autophagy in breast cancer MCF-7 cells. Molecular and Cellular Biochemistry 2016; 417 (1-2): 35-47. 
• Misztal T, Rusak T, Brańska-Januszewska J, Ostrowska H, Tomasiak M. : Peroxynitrite may affect fibrinolysis via the reduction of platelet-related fibrinolysis resistance and alteration of clot structure. Free Radical Biology & Medicine. 2015; 89: 533-547.
• Ołdziej A., Bolkun L., Galar M., Kalita J., Ostrowska H., Romaniuk W., Kloczko J.: Assessment of proteasome concentration and chymotrypsin-like activity in plasma of patients with newly diagnosed multiple myeloma. Leukemia Research 2014; 38: 925-930.

• Hempel D., Wojtukiewicz M.Z., Kozłowski L., Romatowski J., Ostrowska H.: Increased plasma proteasome chymotrypsin-like activity in patients with advanced solid tumors. Tumor Biol 2011; 32: 753-759.
• Gorodkiewicz E., Ostrowska H., Sankiewicz A.: SPR imaging biosensor for the 20S proteasome: sensor development and application to measurement of proteasomes in human blood plasma. Microchim Acta 2011; 175: 177-184.
• Orłowska M., Kulikowska-Karpińska E., Ostrowska H.: Wodne Hyphomycetes w rzece Narewka. Ochrona Środowiska i Zasobów Naturalnych 2009; 40: 524-532.
• Ostrowska H., Hempel D., Hołub M., Sokołowski J., Kłoczko J.: Assessment of circulating proteasome chymotrypsin-like activity in plasma of patients with acute and chronic leukemias. Clin Biochem 2008; 41: 1377-1383.
• Ostrowska H.: The ubiquitin-proteasome system: a novel target for anticancer and antiiflammatory drug research. Cell Mol Biol Lett 2008; 13: 353-365.
• Ostrowska H., Wojtukiewicz M.: Pharmacology of the ubiquitin proteasome system: proteasome inhibitors and modulators. W: The ubiquitin proteasome system in the central nervous system: from physiology to pathology. Eds: Mario Di Napoli, Cezary Wojcik. New York: Nova Science Publishers, 2007, str. 961-987.
• Orłowska M., Kulikowska-Karpińska E., Lengiewicz I., Ostrowska H.: Hyphomycetes developing in the water, near the dumping ground of waste. Pol J Environ Stud 2007; 16: 443-448.
• Ostrowska H., Kruszewski K., Kasacka I.: Immuno-proteasome subunit LMP7 is up-regulated in the ischemic kidney in experimental model of renovascular hypertension. IJBCB 2006; 38: 1778 – 1785.
• Orłowska M., Lengiewicz I., Ostrowska H.: Conidial fungi on plants in the Biebrzański National Park. Acta Hydrochim Hydrobiol 2006; 34: 53-57.
• Ostrowska H., Kalinowska J., Chabielska E., Stankiewicz A., Kruszewski K., Buczko W.: Ebelactone B, an inhibitor of extracellular cathepsin A-type enzyme, suppresses platelet aggregation ex vivo in renovascular hypertensive rats. J Cardiov Pharmacol. 2005; 45: 348-353.