Medical University of Bialystok. Head.
  • 28.02.2023 Zakład Fizjologii i Patofizjologii Doświadczalnej

    Head

    Prof. Dr. Barbara Malinowska

    e-mail: barbara.malinowska@umb.edu.pl

    Head of the Department of Experimental Physiology and Pathophysiology

    Medical University of Białystok (Poland)

    Website: https://www.umb.edu.pl/en/s,21780/Head

     

    Key research interests:

    • Cannabinoid mechanisms in the regulation of the cardiovascular system under physiological and pathophysiological conditions.
    • Regulation of the cardiovascular system by presynaptic receptors.
    • Atypical ß-adrenoceptors: Search for models and investigation of ad hoc synthesized ligands.

     

    Scientific grants funded by National Science Centre (Poland):

    • Complex effects of cannabidiol on the cardiovascular system, oxidative stress and heart metabolism in experimental models of hypertension (OPUS; 2016 – 2019)
    • Role of endocannabinoids in the regulation of the cardiovascular system, oxidative stress and heart metabolism in the models of primary and secondary hypertension (OPUS; 2012 – 2016)

     

    Technologies/resources:

     

    List of publications from the last ten years:

    • Remiszewski P, Jarocka-Karpowicz I, Biernacki M, Jastrząb A, Schlicker E, Toczek M, Harasim-Symbor E, Pędzińska-Betiuk A, Malinowska B.: Chronic cannabidiol administration fails to diminish blood pressure in rats with primary and secondary hypertension despite its effects on cardiac and plasma endocannabinoid system, oxidative stress and lipid metabolism. Int J Mol Sci. 2020;21. pii: E1295.
    • Malinowska B.., Przegaliński E., Schlicker E.: Prof. Dr. med. Dr. h. c. mult. Manfred Göthert. Obituary. Pharmacol. Rep. 2020.
    • Göthert M., Bönisch H., Malinowska B., Schlicker E.: Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred Göthert. Pharmacol. Rep. 2020.
    • Malinowska B., Toczek M., Pędzińska-Betiuk A., Schlicker E. Cannabinoids in arterial, pulmonary and portal hypertension - mechanisms of action and potential therapeutic significance. Br J Pharmacol. 2019;176:10:1395-1411.
    • Kossakowski R., Schlicker E., Toczek M., Weresa J., Malinowska B.: Cannabidiol affects the Bezold-Jarisch reflex via TRPV1 and 5-HT3 receptors and has peripheral sympathomimetic effects in spontaneously hypertensive and normotensive rats. Front Pharmacol. 2019;10:500.
    • Baranowska-Kuczko M., Kozłowska H., Kloza M., Sadowska O., Kozłowski M., Kusaczuk M., Kasacka .I, Malinowska B.: Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities. J Hypertens. 2019. doi: 10.1097/HJH.0000000000002333.
    • Weresa J., Pędzińska-Betiuk A., Kossakowski R., Malinowska B.: Cannabinoid CB1 and CB2 receptors antagonists AM251 and AM630 differentially modulate the chronotropic and inotropic effects of isoprenaline in isolated rat atria. Pharmacol Rep. 2019;71:82-89.
    • Harasim-Symbor .E, Polak A., Pędzińska-Betiuk A., Weresa .J, Malinowska B., Lewandowska A., Kasacka .I, Chabowski. A.: Fatty acid amide hydrolase inhibitor (URB597) as a regulator of myocardial lipid metabolism in spontaneously hypertensive rats. Chem Phys Lipids. 2019;218:141-148.
    • Toczek M., Malinowska B. Enhanced endocannabinoid tone as a potential target of pharmacotherapy. Life Sci. 2018;204:20-45.
    • Biernacki M., Malinowska B., Timoszuk M., Toczek M., Jastrząb A., Remiszewski P., Skrzydlewska E.: Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins Other Lipid Mediat. 2018;138:54-63.
    • Karpińska O., Baranowska-Kuczko M., Malinowska B., Kloza M., Kusaczuk M., Gęgotek A.,Golec P., Kasacka .I, Kozłowska H.: Mechanisms of l-alpha-lysophosphatidylinositol-induced relaxation in human pulmonary arteries. Life Sci. 2018;192:38-45.
    • Polak A., Harasim-Symbor E., Malinowska B., Kasacka .I, Lewandowska A, Chabowski A.: The endocannabinoid system affects myocardial glucose metabolism in the DOCA-Salt model of hypertension. Cell Physiol Biochem. 2018;46:727-739.
    • Grzęda E., Schlicker E., Toczek M., Zalewska I., Baranowska-Kuczko M., Malinowska B.: CB1 receptor activation in the rat paraventricular nucleus induces bi-directional cardiovascular effects via modification of glutamatergic and GABAergic neurotransmission. Naunyn Schmiedebergs Arch. Pharmacol. 2017;390:25-35.
    • Karpińska O., Baranowska-Kuczko M., Kloza M., Ambrożewicz E., Kozłowski T., Kasacka I., Malinowska B., Kozłowska H.: Activation of CB1 receptors by 2-arachidonoylglycerol attenuates vasoconstriction induced by U46619 and angiotensin II in human and rat pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2017;313:R883-R893.
    • Pędzińska-Betiuk A., Weresa J., Toczek M., Baranowska-Kuczko M., Kasacka I., Harasim- Symbor E., Malinowska B.: Chronic inhibition of fatty acid amide hydrolase by URB597  produces differential effects on cardiac performance in normotensive and hypertensive rats. Br J Pharmacol. 2017;74 :2114-2129.
    • Polak A., Harasim-Symbor E., Malinowska B., Kasacka I., Pędzińska-Betiuk A., Weresa J., Chabowski A. : The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats. Life Sci. 2017;183:1-10.
    • Kloza M.,Baranowska-Kuczko M., Malinowska B., Karpińska O., Harasim-Symbor E., Kasacka I., Kozłowska H.: The influence of DOCA-salt hypertension and chronic administration of the FAAH inhibitor URB597 on KCa2.3/KCa3.1-EDH-type relaxation in rat small mesenteric arteries. Vascul Pharmacol. 2017;99:65-73.
    • Baranowska-Kuczko M., Kozłowska H., Kloza M., Karpińska O., Toczek M., Harasim E., Kasacka I., Malinowska B.: Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats. Life Sci. 2016;151:288-99.
    • Toczek M., Baranowska-Kuczko M., Grzęda E., Pędzińska-Betiuk A., Weresa J., Malinowska B.: Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats. Pharmacol Rep. 2016;68:363-9.
    • Karabowicz P., Schlicker E., Pędzińska-Betiuk A., Kloza M., Malinowska B.: The adrenal medulla, not CB1 receptors, mediates the inhibitory effect of acute transverse aortic constriction on  the neurogenic vasopressor response. Life Sci. 2015;138:86-93.
    • Toczek M., Schlicker E., Grzęda E., Malinowska B.: Enhanced function of inhibitory presynaptic cannabinoid CB1 receptors on sympathetic nerves of DOCA-salt hypertensive rats. Life Sci. 2015;138:78-85.
    • Grzęda E., Schlicker E., Luczaj W., Harasim E., Baranowska-Kuczko M, Malinowska B.: Bi-directional CB1 receptor-mediated cardiovascular effects of cannabinoids in anaesthetized rats: role of the paraventricular nucleus. J Physiol Pharmacol. 2015 66:343-53.
    • Baranowska-Kuczko M., Kozłowska H., Kozłowski M., Schlicker E., Kloza M., Surażyński A., Grzęda E., Malinowska B.: Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries. Naunyn-Schmiedeberg’s Arch. Pharmacol., 2014; 387:477-86.
    • Karabowicz P., Grzęda E., Baranowska-Kuczko M., Malinowska B.: Znaczenie endokannabinoidu 2-arachidonyloglicerolu w fizjologii i patofizjologii układu krążenia. Postępy Hig Med Dośw,  2014: 68:814-827.
    • Schlicker E., Pędzińska-Betiuk A., Kozłowska H., Szkaradek N., Zelaszczyk D., Baranowska-Kuczko M., Kieć-Kononowicz .K, Marona H, Malinowska B. :MH-3: evidence for non-competitive antagonism towards the low-affinity site of β1-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:743-52.
    • Ilayan E., Feliszek M., Malinowska B., Schlicker E.: Do cannabinoids exhibit a tyramine-like effect? Naunyn Schmiedebergs Arch Pharmacol. 2013;386:1041-1046.
    • Kozłowska H., Baranowska-Kuczko M., Schlicker E., Kozłowski M., Kloza M., Malinowska B.: Relaxation of human pulmonary arteries by PPARγ agonists. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:445-453.
    • Malinowska B., Baranowska-Kuczko M., Schlicker E.: Triphasic blood pressure responses to cannabinoids: do we understand the mechanism? Br J Pharmacol. 2012;165:2073-2088.
    • Baranowska-Kuczko M., Margaret R., MacLean MR., Kozłowska H., Malinowska B.: Endothelium-dependent mechanisms of the vasodilatory effect of endocannabinoid anandamide in the rat pulmonary artery. Pharmacol Res 2012;66:251-259.
    • Rudź R., Schlicker E., Baranowska U., Marciniak J., Karabowicz P., Malinowska B.: Acute myocardial infarction inhibits the neurogenic tachycardic and vasopressor response in rats via presynaptic cannabinoid type 1 receptor. J Pharmacol Exp Ther. 2012;343:198-205.
    • Kozłowska H., Baranowska-Kuczko M., Schlicker E., Kozłowski M., Zakrzeska A., Grzęda E., Malinowska B.: EP3 receptor-mediated contraction of human pulmonary arteries and inhibition of neurogenic tachycardia in pithed rats. Pharmacol Rep 2012;64:1526-36.
    • Lupiński S.Ł., Schlicker E., Pędzińska-Betiuk A., Malinowska B.: Acute myocardial ischemia enhances the vanilloid TRPV1 and serotonin 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats. Pharmacol Rep. 2011;63:1450-1459.
    • Malinowska B., Zakrzeska A., Kurz C. M., Göthert M., Kwolek G., Wielgat P., Braszko J. J., Schlicker E.: Involvement of central β2-adrenergic, NMDA and thromboxane A2 receptors in the pressor effect of anandamide in rats. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2010;381:349-360.
    • Zakrzeska A., Schlicker E., Baranowska M., Kozłowska H., Kwolek G., Malinowska B.: A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats. Br. J. Pharmacol. 2010;160:574-584.
    • Günther J., Schulte K., Wenzel D., Malinowska B., Schlicker E.: Prostaglandins of the E series inhibit monoamine release via EP3 receptors: proof with the competitive EP3  receptor antagonist L-826,266. Naunyn Schmiedeberg‘s Arch. Pharmacol. 2010;381:21-31.
    • Pędzińska-Betiuk A., Hryniewicz A., Łupiński S.Ł., Malinowska B.: Nowe aspekty w farmakologii receptorów β-adrenergicznych w niewydolności mięśnia sercowego. Polski Przegląd Kardiologiczny, 2010;12:131-137.
In order to provide services at the highest level, we use cookies. Using our website means that they will be stored on your device. You can change your browser settings at any time.
See cookies policy.
I accept
Zamknij