Medical University of Bialystok. Research & Science.

Research

Physiological and pharmacological regulation of collagen metabolism
Mechanism of toxic drug effects on collagen metabolism
Drug Analysis according Polish Pharmacopeia VIII

Techniques

Cell cultures
Western immunoblot
Electrophoretic and chromatographic techniques
atomic absorption spectrometry
spectrofluorimetry
DSC
IR
UV/Vis
HPLC

Publications

Garley M., Jabłońska E., Dziemiańczyk-Pakieła D., Miltyk W., Ratajczak-Wrona W., Borys J., Moniuszko M., Grubczak K. LDGs versus NDGs in patients with oral squamous cel carcinoma (OSCC). Cytokine 2021 : 137, 9 pp, Article ID 155311
Tafazoli A., Guchelaar H., Miltyk W., Krętowski A., Swen J. Applying next-generation sequencing platforms for pharmacogenomic testing in clinical practice.
Frontiers in Pharmacology, 2021 : 12, 15 pp, Article ID 693453
Tafazoli A., Guggilla R., Kamel-Koleti Z., Miltyk W. Strategies to improve the clinical outcomes for direct-to-consumer pharmacogenomic tests. Genes, 2021 : 12, 3, 13 pp, Article ID 361
Baszanowska W., Misiura M., Ościłowska I., Pałka J., Miltyk W. Extracellular prolidase (PEPD) induces anabolic processes through EGFR, ß1-integrin, and IGF-1R signaling pathways in an experimental model of wounded fibroblasts. International Journal of Molecular Sciences, 2021 : 22, 13 pp, Article ID 942
Misiura M., Guszczyn T., Ościłowska I., Baszanowska W., Pałka J., Miltyk W. Platelet-rich plasma promotes the proliferation of human keratinocytes via a progression of the cell cycle. A role of prolidase.International Journal of Molecular Sciences, 2021 : 22, 14 pp, Article ID 936
Tafazoli A., Wołczyński S., Wawrusiewicz-Kurylonek N., Esmaeili S.-A., Miltyk W. Pharmacogenomic biomarkers of follicle-stimulating hormone receptor malfunction in females with impaired ovarian response - a genetic survey. Journal of Clinical Medicine, 2021: 10, 2, 14 pp, Article ID 170
Tafazoli Alireza, Wawrusiewicz-Kurylonek Natalia, Posmyk Renata, Miltyk Wojciech. Pharmacogenomics, how to deal with different types of variants in next generation sequencing data in the personalized medicine area. Journal of Clinical Medicine, 2021 : 10, 24 pp, Article ID 34
Pietkiewicz D., Klupczyńska-Gabryszak A., Plewa Sz., Misiura M., Horala A., Miltyk W., Nowak-Markwitz E., Kokot Z., Matysiak J. Free amino acid alterations in patients with gynecological and breast cancer: a review. Pharmaceuticals, 2021 : 14, 8, 27 pp, Article ID 731
Misiura M., Ościłowska I., Bielawska K., Pałka J., Miltyk W. PRODH/POX-dependent celecoxib-induced apoptosis in MCF-7 breast cancer. Pharmaceuticals, 2021 : 14, 9, 13 pp, Article ID 874
Garley M., Jabłońska E., Miltyk W., Grubczak K., Surażyński A., Ratajczak-Wrona W., Grudzińska M., Nowacka K., Moniuszko M., Pałka J, Borys J., Dziemiańczyk-Pakieła D. Cancers cells in traps? The pathways of NETs formation in response to OSCC in humans – a pilot study. Cancer Control, 2020 : 27, 1, 10 pp
Tołoczko-Iwaniuk N., Dziemiańczyk-Pakieła D., Celińska-Janowicz K., Zaręba I., Klupczyńska A., Kokot Z., Nowaszewska B. K., Reszeć J., Borys J., Miltyk W. Proline dependent induction of apoptosis in oral squamous cell carcinoma (OSCC) - the effect of celecoxib. Cancers, 2020 : 12, 1, 18pp., Article ID 136
Makvandi P., Ghomi M., Ashrafizadeh M., Tafazoli A., Agarwal T., Delfi M., Akhtari J., Zare Ehsan N., Padil V., Zarrabi A., Pourreza N., Miltyk W., Maiti Tapas K. A review on advances in graphene-derivative/polysaccharide bionanocomposites: Therapeutics, pharmacogenomics and toxicity. Carbohydrate Polymers, 2020 : 250, 19 pp, Article ID 116952
Khazeei Tabari M. A., Khoshhal H., Tafazoli A., Khandan M., Bagheri A. Applying computer simulations in battling with COVID-19, using pre-analyzed molecular and chemical data to face the pandemic. Informatics in Medicine Unlocked, 2020 : 21, 7 pp, Article ID 100458 Misiura M., Miltyk W. Current understanding of the emerging role of prolidase in cellular metabolism. International Journal of Molecular Sciences, 2020 : 21, 16, 20 pp, Article ID 5906
Misiura M., Baszanowska W., Ościłowska I., Pałka J., Miltyk W. Prolidase stimulates proliferation and migration through activation of the PI3K/Akt/mTOR signaling pathway in human keratinocytes. International Journal of Molecular Sciences, 2020 : 21, 23, 20 pp, Article ID 9243
Parizi Payam K., Yarahmadi F., Tabar Hoseins M., Hosseini Z., Sarli A., Kia N, Tafazoli A., Esmaeili S-A. MicroRNAs and target molecules in bladder cancer. Medical Oncology, 2020, 37, 33 pp, Article ID 118
Klupczyńska A., Misiura M., Miltyk W., Ościłowska I., Pałka J., Kokot Z., Matysiak J. Development of an LC-MS targeted metabolomics methodology to study proline metabolism in mammalian cell cultures. Molecules, 2020 : 25, 20, 13 pp, Article ID 4639
Teul J., Deja S., Celińska-Janowicz K., Ząbek A., Młynarz P., Barć P., Junka A, Smutnicka D., Bartoszewicz M., Pałka J., Miltyk W. LC-QTOF-MS and ¹H NMR metabolomics verifies potential use of greater omentum for Klebsiella pneumoniae biofilm eradication in rats. Pathogens, 2020 : 9, 5, 21 pp., Article ID 399
Misiura M., Miltyk W. Proline-containing peptides - new insight and implications: a review. Biofactors, 2019 : 45, 6, s. 857-866
Tołoczko-Iwaniuk N., Dziemiańczyk-Pakieła D., Nowaszewska B. K., Celińska-Janowicz K., Miltyk W.Celecoxib in Cancer Therapy and Prevention - Review.Current Drug Targets, 2019: 20, 3, s. 302-315
Ponikwicka-Tyszko D., Chruściel M., Stelmaszewska J., Bernaczyk P., Chrusciel P., Sztachelska M., Scheinin M., Bidziński M., Szamatowicz J., Huhtaniemi I., Wołczyński S., Rahman N. Molecular mechanisms underlying mifepristone's agonistic action on ovarian cancer progression. EBioMedicine, 2019 : 47, s. 170-183
Tafazoli A., Behjati F., Farhud D., Abbaszadegan M. R. Combination of genetics and nanotechnology for down syndrome modification: A potential hypothesis and review of the literature. Iranian Journal of Public Health, 2019 : 48, 3, s. 371-378
Akbari Kordkheyli V., Khonakdar T. A., Mishan M., Tafazoli A., Bardania H., Zarpou S., Bagheri A. Effects of quercetin on microRNAs: A mechanistic review. Journal of Cellular Biochemistry, 2019 : 120, 8, s. 12141-12155
Sawczuk R., Karpińska J., Miltyk W. What do we know and what we would like to know about drone homogenate. Journal of Ethnopharmacology, 2019 : 245, Article ID 111581
Zbucka-Krętowska M., Łazarek U., Miltyk W., Sidorkiewicz I., Pierzyński P., Milewski R., Wołczyński S., Czerniecki J. Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy. Journal of Perinatal Medicine, 2019 : 47, 7, s. 765-770
Tołoczko-Iwaniuk N., Dziemiańczyk-Pakieła D., Celińska-Janowicz K., Drągowski P., Groth D., Reszeć J., Car H., Borys J., Miltyk W. The effect of metronidazole on the viability of CAL-27 tongue cancer cells. Acta Poloniae Pharmaceutica - Drug Research, 2018 : 75, 5, s. 1233-1240
Osińska M., Rysiak E., Zaręba R., Worona P., Kazberuk A., Prokop I., Celińska-Janowicz K., Zaręba I. Zakażenia szpitalne w aspekcie prawnym. Anestezjologia i Ratownictwo, 2018 : 12, s. 353-356
Ebrahimzadeh M., Tafazoli A., Akhtari J., Biparva P., Eslami S. Engineered silver nanoparticles, a new nanoweapon against cancer. Anti-Cancer Agents in Medicinal Chemistry, 2018 : 18, 14, s. 1962-1969
Zbucka-Krętowska M., Zbucki R., Parfieniuk E., Maslyk M., Lazarek U., Miltyk W., Czerniecki J., Wołczyński S., Krętowski A., Ciborowski M. Evaluation of Bisphenol A influence on endocannabinoid system in pregnant women. Chemosphere, 2018 : 203, s. 387-392
Kołodziejczyk P., Gromotowicz-Popławska A., Aleksiejczuk M, Chabielska E., Tutka P., Miltyk W. New sides of aldosterone action in cardiovascular system as potential targets for therapeutic intervention. Current Drug Targets, 2018 : 19, 16, s. 1968-1979
Celińska-Janowicz K., Zaręba I., Lazarek U., Teul J., Tomczyk M., Pałka J., Miltyk W. Constituents of propolis: chrysin, caffeic acid, p-coumaric acid, and ferulic acid induce PRODH/POX-dependent apoptosis in human tongue squamous cell carcinoma cell (CAL-27). Frontiers in Pharmacology, 2018 : 9, article 336, 12 pp
Liżewska B., Teul J., Kuć P., Lemancewicz A., Charkiewicz K., Gościk J., Kacerovsky M., Menon R., Miltyk W., Laudański P. Maternal plasma metabolomic profiles in spontaneous preterm birth: preliminary results. Mediators of Inflammation, 2018, Article ID 9362820, 13 pp.
Tomczykowa M., Wróblewska M., Winnicka K., Wieczorek P., Majewski P., Celińska- Janowicz K., Sawczuk R., Miltyk W., Tryniszewska E., Tomczyk M. Novel gel formulations as topical carriers for the essential oil of Bidens tripartita for the treatment of candidiasis. Molecules, 2018 : 23, 10, E2517, 10 pp.
Zaręba I., Celińska-Janowicz K., Surażyński A., Miltyk W., Pałka J. Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. Oncotarget, 2018 : 9, 17, s. 13748-13757
Siemieniuk M., Sosnowska K., Czerniecki J., Czyżewska U., Winnicka K., Tylicki A. Oxythiamine improves antifungal activity of ketoconazole evaluated in canine Malassezia pachydermatis strains. Veterinary Dermatology, 2018 : 29, 6, s. 476-e160
Zaręba I., Surażyński A., Chruściel M., Miltyk W., Doroszko M., Rahman N., Pałka J. Functional consequences of intracellular proline levels manipulation affecting PRODH/POX dependent pro-apoptotic pathways in a novel in vitro cell culture model. Cellular Physiology and Biochemistry, 2017 : 43, 2, s. 670-684
Moczydłowska J., Miltyk W., Hermanowicz A., Lebensztejn D. M., Pałka J., Dębek W. HIF-1 alpha as a key factor in bile duct ligation-induced liver fibrosis in rats. Journal of Investigative Surgery, 2017 : 30, 1, s. 41-46
Celińska-Janowicz K., Zaręba I., Drągowski P., Teul J., Sawczuk R., Kazberuk A., Rysiak E., Miltyk W. Nanocząstki srebra i ich zastosowanie w medycynie. Polski Przegląd Nauk o Zdrowiu, 2017, 3 (52), s. 385-389
Drozdowska D., Rusak M., Miltyk W., Markowska A., Samczuk P. Antiproliferative effects on breast cancer cells and some interactions of new distamycin analogues with DNA, endonucleases and DNA topoisomerases. Acta Poloniae Pharmaceutica Drug Research, 2016: 73, 1, s. 47-53
Mazurek-Wądołkowska E., Winnicka K., Czyżewska U., Miltyk W. Effect of simultaneously silicified microcrystalline cellulose and pregelatinized starch on the theophylline tabletes stability. Acta Poloniae Pharmaceutica Drug Research, 2016 : 73, 4, s. 1029-1036
Siemionow [S.D.] K., Teul J., Drągowski [S.D.] P., Pałka J., Miltyk W. New potential biomarkers of acetaminophen-induced hepatotoxicity. Advances in Medical Sciences, 2016 : 61, 2, s. 325-330
Sawczuk R., Miltyk W. Ostropest plamisty - stare/nowe panaceum. Gazeta Farmaceutyczna, 2016 : 25, 4 (288), s. 22-24
Siemionow [S.D.] K., Miltyk W. Propolis - charakterystyka i zastosowanie w przemyśle farmaceutycznym. Gazeta Farmaceutyczna, 2016 : 25, 3 (287), s. 22-24
Kałaska B., Ciborowski M., Domaniewski T., Czyżewska U., Godzień J. B., Miltyk W., Krętowski A., Pawlak D. Serum metabolic fingerprinting after exposure of rats to quinolinic acid. Journal of Pharmaceutical and Biomedical Analysis, 2016 : 131, s. 175-182
Szymańska E., Szekalska M., Czarnomysy R., Lavric Z., Srcic S., Miltyk W., Winnicka K. Novel spray dried glycerol 2-phosphate cross-linked chitosan microparticulate vaginal delivery systemdevelopment, characterization and cytotoxicity studies. Marine Drugs, 2016 : 14, 10, 12 pp.
Czyżewska U., Siemionow [S.D.] K, Zaręba I, Miltyk W. Proapoptotic activity of propolis and their components on human tongue squamous cell carcinoma cell line (CAL-27).PLoS ONE, 2016 : 11, 6, s. e0157091
Siemionow [S.D.] K., Drągowski [S.D.] P., Teul J., Sawczuk R., Zaręba [S.D.] I., Miltyk W. Charakterystyka zawodu diagnosty laboratoryjnego i jego rola w systemie opieki zdrowotnej w Polsce. Polski Przegląd Nauk o Zdrowiu, 2016 : 1, 46, s. 110-112
Konończuk J., Surażyński A., Czyżewska U., Prokop I., Tomczyk M., Pałka., Miltyk W. Alphallbbeta3-integrin ligands: Abciximab and Eptifibatide as proapoptotic factors in MCF-7 human breast cancer cells. Current Drug Targets, 2015 : 16, 13, s. 1429-1437
Konończuk J., Czyżewska U., Moczydłowska J., Surażyński A., Pałka J., Miltyk W. Proline oxidase (POX) as a target for cancer therapy. Current Drug Targets, 2015 : 16, 13, s. 1464-1469
Donejko [S.D.] M., Przylipiak A., Rysiak E., Miltyk W., Galicka E., Przylipiak J., Zaręba I., Surażyński A. Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts. Drug Design, Development and Therapy, 2015 : 9, s. 6225-6233
Kołodziejczyk P., Miltyk W. Substancje uzależniające dostępne bez recepty. Gazeta Farmaceutyczna, 2015 : 24, 2(274), s. 28-30
Komarowska M. D., Hermanowicz A., Czyżewska U., Milewski R., Matuszczak E., Miltyk W., Dębek W. Serum bisphenol a level in boys with cryptorchidism: a step to male infertility? International Journal of Endocrinology, 2015, Article ID 973154, 8 pp.
Czyżewska U., Konończuk J., Teul J., Drągowski [S.D.] P., Pawlak-Morka R., Surażyński A., Miltyk W. Verification of chemical composition of commercially available propolis extracts by gas chromatography-mass spectrometry analysis. Journal of Medicinal Food, 2015 : 18, 5, s. 584-591
Szymańska E., Sosnowska K., Miltyk W., Rusak M., Basa A., Winnicka K. The effect of beta-glycerophosphate crosslinking on chitosan cytotoxicity and properties of hydrogels for vaginal application. Polymers, 2015 : 7, 11, s. 2223-2244
Kołodziejczyk P., Miltyk W. Preparaty wzmacniające odporność. Gazeta Farmaceutyczna, 2014 : 23, 2, s. 16
Drągowski [S.D.] P, Czyżewska U., Cekała E., Lange P., Zadykowicz R, Sójka A., Brzezińska J. Cukrzyca jako problem społeczny i ekonomiczny. Polski Przegląd Nauk o Zdrowiu, 2014 : 2, 39, s. 163-166
Zadykowicz R., Sójka A., Czyżewska U., Rutkowski M., Kilen K., Rysiak E., Miltyk W. Menopauza w aspekcie społecznym i ekonomicznym. Polski Przegląd Nauk o Zdrowiu, 2014: 2, 39, s. 127-132
Mazurek-Wądołkowska E., Winnicka K., Czajkowska-Kośnik A., Czyżewska U., Miltyk W. Application of differential scanning calorimetry in evaluation of solid state interactions in tablets containing acetaminophen. Acta Poloniae Pharmaceutica Drug Research, 2013 : 70, 5, s. 787-793
Sadowska A., Prokopiuk S., Miltyk W., Surażyński A., Konończuk J., Sawicka D., Car H. Metronidazole affects breast cancer cell lines. Advances in Medical Sciences, 2013 : 58, 1, s. 90-95
Surażyński A., Miltyk W., Prokop I., Pałka J. The effect of estrogen on prolidase-dependent regulation of HIF-1alpha expression in breast cancer cells. Molecular and Cellular Biochemistry, 2013 : 379, 1-2, s. 29-36
Surażyński A., Miltyk W., Wołczyński S., Pałka J. The effect of prolactin and estrogen cross talk on prolidase - dependent signaling in MCF-7 cells. Neoplasma, 2013 : 60, 4, s. 355-363

Rupérez F.J., Ramos-Mozo P., Teul J., Martinez-Pinna R., Garcia A., Malet-Martino M., Camafeita E., Lopez J.A., Pastor-Vargas C., Egido J., Balayssac S., Gilard V., Barbas C., Martin-Ventura J.L.: Metabolomic study of plasma of patients with abdominal aortic aneurysm. Anal Bioanal Chem. 2012. 403(6). 1651-1660.
Ciborowski M., Teul J., Martin-Ventura J.L., Egido J., Barbas C.: Metabolomics with LC-QTOF-MS Permits the Prediction of Disease Stage in Aortic Abdominal Aneurysm Based on Plasma Metabolic Fingerprint. PLoS ONE. 2012. 7(2). e31982. doi: 10.1371 /journal.pone.0031982
Teul J., Garcia A., Tuñón J., Martin-Ventura J.L., Tarín N., Bescós L.L., Egido J., Barbas C., Rupérez F.J.: Targeted and non-targeted metabolic time trajectory in plasma of patients after acute coronary syndrome. J Pharm Biomed Anal. 2011. Sep 10;56(2). 343-351.
Miltyk W, Surazynski A, Dondziło J, Palka J. 4'-chlorodiazepam--agonist ofperipheral benzodiazepine receptors as a protecting factor in IL-1 induced deregulation of collagen biosynthesis in cultured human chondrocytes. Eur J Pharmacol. 2010, 25;647(1-3):31-6.
Surazynski A, Miltyk W, Prokop I, Palka J. Prolidase-dependent regulation of TGF c and TGF β receptor expressions in human skin fibroblasts. Eur J Pharmacol. 2010, 15;649(1-3):115-9.
Markowska A, Bruzgo I, Miltyk W, Midura-Nowaczek K. Synthesis and activity of N-sulfonylamides of tripeptides as potential urokinase inhibitors. Protein Pept Lett. 2010; 17(10):1300-4.
Winnicka K, Bielawski K, Bielawska A, Miltyk W. Dual effects of ouabain, digoxin and proscillaridin A on the regulation of apoptosis in human fibroblasts. Nat Prod Res. 2010; 24(3):274-85.
Teul J, Rupérez FJ, Garcia A, Vaysse J, Balayssac S, Gilard V, Malet-Martino M, Martin-Ventura JL, Blanco-Colio LM, Tuñón J, Egido J, Barbas C. Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints. J Proteome Res. 2009; 8(12):5580-9.
Miltyk W, Surazyński A, Sławomir W, Pałka JA. Combined therapy with disintegrin and melphalan as a new strategy in inhibition of endometrial cancer cell line (Ishikawa) growth. Folia Histochem Cytobiol. 2009; 47(5):S121-5.
Leśniewska M, Miltyk W, Swiatecka J, Tomaszewska M, Kuźmicki M, Pałka J, Wołczyński S. Estrogen receptor beta participate in the regulation of metabolizm of extracellular matrix in estrogen alpha negative breast cancer. Folia Histochem Cytobiol. 2009; 47(5):S107-12.
Stankiewicz-Kranc A, Miltyk W, Skrzydlewska E. Comparison of influence of carmustine and new proline analog of nitrosourea on antioxidant system in breast carcinoma cells (MCF-7). Drug Chem Toxicol. 2010; 33(1):55-63.
Kociecka B, Surazynski A, Miltyk W, Palka J. The effect of Telmisartan on collagen biosynthesis depends on the status of estrogen activation in breast cancer cells. Eur J Pharmacol. 2010; 628(1-3):51-6.
Surazynski A, Jarzabek K, Miltyk W, Wolczynski S, Palka J. Estrogen-dependent regulation of PPAR-gamma signaling on collagen biosynthesis in adenocarcinoma endometrial cells. Neoplasma. 2009; 56(5):448-54.
Surazynski A, Miltyk W, Czarnomysy R, Grabowska J, Palka J. Hyaluronic acid abrogates nitric oxide-dependent stimulation of collagen degradation in cultured human chondrocytes. Pharmacol Res. 2009; 60(1):46-9.