Medical University of Bialystok. Research & Science.

Research

Studies on the role of interleukin-6 (IL-6) in the physiological processes and pathological states in IL-6 knock-out mice (C57BL IL6^-/-tm1Kopf).
Studies on the role of interleukin 6 in ischemic and reperfused myocardium - clinical and experimental studies.
Role of interleukin-6 in aging.
Significance of IL-6 in cognitive processes.
Studies on the effects of cannabinoids on CNS activity and cognitive processes.
Human T-lymphotropic virus type 1(HTLV-1) genes’ polymorphism.
Research on theparticipation of chaperone proteins in the phenomenon of synaptic plasticity.

Techniques

Animal model of myocardial infarction and heart failure in mice.
Animal model of hyperthyroidism and hypothyroidism in mice and rats.
Animal model of diabetes mellitus in mice.
Behavioural tests used for assessment of cognitive functions in mice and rats.
Quantitative and qualitative assessment of genes’ expression.
Histological and immunohistochemical methods.

Collaboration

Department of General and Experimental Pathology collaborates with several departments and clinics of Medical University of Białystok and Nencki Institute of Experimental Biology in Warsaw. Moreover, Department collaborates with Animal Models and Retroviral Vaccines Section (National Cancer Institute) and Neuroimmunology Branch, Viral Immunology Section (National Institute of Neurological Disorders and Stroke) being parts of National Institutes of Health.

Publications

Hilfiker-Kleiner D, Kamiński K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell, 2007;128: 589-600.
Kamiński KA, Oledzka E, Białobrzewska K, Kozuch M, Musiał WJ, Winnicka MM:
The effects of moderate physical exercise on cardiac hypertrophy in interleukin 6 deficient mice.
Adv Med Sci., 2007;52:164-8.
Hryniewicz A, Bialuk I, Kamiński K, Winnicka MM: Impairment of recognition memory in interleukin-6 knock-out mice. Eur. J. Parmacol. 2007, 577: 219-220.
Zbucki RL, Sawicki B, Hryniewicz A, Winnicka MM: Cannabinoids enhance gastric X/A-like cells activity. Folia Histochem Cytobiol., 2008;46(2):219-24.
Dadan J, Zbucki RL, Sawicki B, Winnicka MM: Estimation of gastric ghrelin-positive cells activity in hyperthyroid rats. Folia Histochem Cytobiol. 2008;46(4):511-7.
Kaminski K, Bonda T, Wojtkowska I, Dobrzycki S, Kralisz P, Nowak K, Prokopczuk P, Skrzydlewska E, Kozuch M, Musial WJ: Oxidative stress and antioxidative defense parameters early after reperfusion therapy for acute myocardial infarction. Acute Card Care., 2008, 10(2):121-6.
Chabowski A, Zmijewska M, Gorski J, Bonen A, Kaminski K, Kozuch M, Winnicka MM:
IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle. J Physiol Pharmacol., 2008, 59 Suppl 7:105-17.
Fukumoto R, Andresen V, Bialuk I, Cecchinato V, Walser J-C, Valeri VW, Nauroth JM, Gessain A, Nicot C, Franchini G: In vivo genetic mutations define predominant functions of the Human T-cell leukemia/lymphoma virus p12I protein. Blood, 2009, 113(16):3726-34.
Kaminski KA, Kozieradzka A, Bonda T, Banach M, Kozuch M, Wojtkowska I, Dobrzycki S, Kralisz P, Nowak K, Prokopczuk P, Mikhailidis DP, Musial WJ: Percutaneous coronary interventions affect concentrations of interleukin 6 and its soluble receptors in coronary sinus blood in patients with stable angina. Angiology, 2009, 60(3):322-8.
Kamiński KA, Szepietowska B, Bonda T, Kozuch M, Mencel J, Małkowski A, Sobolewski K, Kovalchuk O, Chyczewski L, Szelachowska M, Górska M, Musiał WJ, Winnicka MM: CCN2 protein is an announcing marker for cardiac remodeling following STZ-induced moderate hyperglycemia in mice. Pharmacol Rep., 2009, 61(3):496-503.
Kamiński KA, Kozuch M, Bonda TA, Stepaniuk MM, Waszkiewicz E, Chyczewski L, Musiał WJ, Winnicka MM: Effect of interleukin 6 deficiency on the expression of Bcl-2 and Bax in the murine heart. Pharmacol Rep., 2009, 61(3):504-13.
Kaminski KA, Kozuch M, Bonda TA, Wojtkowska I, Kozieracka A, Dobrzycki S, Nowak K, Prokopczuk P, Winnicka MM, Musial WJ: Coronary sinus concentrations of interleukin 6 and its soluble receptors are affected by reperfusion and may portend complications in patients with myocardial infarction. Atherosclerosis 2009, 206: 581-587.
Mysliwiec J, Zbucki R, Nikolajuk A, Mysliwiec P, Taranta A, Kaminski K, Bondyra Z, Dadan J, Gorska M, Winnicka MM: Role of interleukin-6 on RANKL-RANK/osteoprotegerin system in hypothyroid ovariectomized mice. Folia Histochem Cytobiol., 2010, 48(4):549-54.
Valeri VW, Hryniewicz A, Andresen V, Jones K, Fenizia C, Bialuk I, Chung HK, Fukumoto R, Parks RW, Ferrari MG, Nicot C, Cecchinato V, Ruscetti F, Franchini G: Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits. Blood, 2010, 116(19):3809-17.
Van Prooyen N, Andresen V, Gold H, Bialuk I, Pise-Masison C, Franchini G:
Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins.
Mol Aspects Med., 2010, 31(5):333-43.
Bonda T, Kaminski KA, Kozuch M, Kozieradzka A, Wojtkowska I, Dobrzycki S, Kralisz P, Nowak K, Prokopczuk P, Musial WJ: Circadian variations of interleukin 6 in coronary circulations of patients with myocardial infarction. Cytokine, 2010, 50(2):204-9.
Bialuk I, Winnicka MM: AM251, cannabinoids receptors ligand, improves recognition memory in rats. Pharmacol Rep.,2011, 63(3):670-9.
Mysliwiec J, Zbucki R, Nikolajuk A, Mysliwiec P, Kaminski K, Bondyra Z, Dadan J, Gorska M,Winnicka MM: Estrogens modulate RANKL-RANK/osteoprotegerin mediated interleukin-6 effect on thyrotoxicosis-related bone turnover in mice. Horm Metab Res., 2011, 43(4):236-40.
Bialuk I, Whitney S, Andresen V, Florese RH, Nacsa J, Cecchinato V, Valeri VW, Heraud JM, Gordon S, Parks RW, Montefiori DC, Venzon D, Demberg T, Guroff MR, Landucci G, Forthal DN, Franchini G. Vaccine., 2011, 30(1):78-94.