Department of Medical Biochemistry conducts studies over biochemistry of extracellular matrix, particularly over:

• characterization of tumour and vascular wall collagens and glycosaminoglycans
• the extracellular matrix of umbilical cord
• the part of growth factors in the reconstruction of extracellular matrix
• the pathobiochemistry of extracellular matrix metalloproteinases

The most important achievements of last years

• The description of umbilical cord extracellular matrix remodelling during pre-eclampsia.
• Characterization of some tumours collagens and proteoglycans.
• The demonstration of peptide growth factors accumulation in extracellular matrix.
• The description of extracellular matrix metalloproteinases significance in extracellular matrix remodelling during some pathological states.

Applied investigative techniques

• Western Immunoblot
• Zymography
• Enzyme-Linked Immunosorbent Assay (ELISA)
• High-Performance Liquid Chromatography (HPLC)
• Thin Layer Chromatography (TLC)
• Polymerase Chain Reaction (PCR)
• Enzymatic assays
• Cell cultures