Medical University of Bialystok. Syllabus 2024/2025.

SYLLABUS

Academic year 2024/2025

Name of a course / module	Regenerative Medicine
Name of a department where course is held	Department of Regenerative Medicine and Immune Regulation
E-mail of department	Marcin.Moniuszko@umb.edu.pl
Faculty of	Medicine with Division of Dentistry and Division of Medical Education in English
Name of a field of study	Medicine
Level of education	Uniform master’s degree studies
Form of study	full time ¢ part time £
Language of instruction	Polish £ English ¢
Type of course	obligatory ¢ facultative £
Year of study / Semester	I £ II ¢ III £ IV £ V £ VI £	1 £ 2 £ 3 ¢ 4 £ 5 £ 6 £ 7 £ 8 £ 10 £ 11 £ 12 £
Introductory courses with preliminary requirements	Student should obtain obligatory credit of biophysics, chemistry, biochemistry and histology, cytophysiology and embryology.
Number of didactic hours with specification of forms of conducting classes	Lectures: 10 Classes: 5
Assumptions and aims of the course	Upon completion of the course students will get the knowledge in: 1. Basic principles of regeneration, healing and aging. 2. Laboratory research in the field of regenerative medicine and it’s clinical applications. 3. How to utilize basic laboratory technics and to plan simple experiments.
Didactic methods	- lectures with a discussion, - consultation (group or individual for the request of the students), - self-study, - other practical classes (observations, individual experiments), - presentation of an experiment carried out during the classes
Full name of the person conducting the course	Kamil Krzysztof Grubczak, PhD
Full name of the person responsible for teaching	Professor Marcin Moniuszko, MD, PhD

Symbol and number of learning outcomes according to the teaching standards and other learning outcomes	Description of directional learning outcomes	Form of classes		Verification methods for achieving intended learning outcomes
Knowledge
B.W21	Knows the mechanisms of cell-cell and cell-extracellular matrix interactions, but also intracellular signaling pathways and examples of disorders in these processes		lectures	Summarizing methods: - written final test Forming methods: - observation of the student's work - evaluation of the activity in the classroom - assessment of preparation for classes - discussion in class
B.W22	Knows the processes: cell cycle, proliferation, differentiation, aging, apoptosis, necrosis and their functions in human body		lectures
B.W23.	Knows the basics of stem cells and their clinical applications		lectures
B.W28.	Knows the mechanisms of aging		lectures
B.W34	Knows the basics of research (observations, experiments, in vitro), which may lead to the development of medicine		lectures
C.W1	Knows the basic definitions in genetics		lectures
C.W19	Knows the basics of disinfection, sterilization and aseptic work		lectures
C.W26	Knows the basic mechanisms of cell and tissue injury		lectures
C.W27	Describes clinical course of innate and adaptive immune responses, but also describes processes of tissue and organ regeneration		lectures
Skills
B.U14	Knows how to plan and carry out an experiment and how to obtain results and draw a conclusion			Summarizing methods: - realization of a specific task - project, presentation Forming methods: - observation of the student's work - evaluation of the activity in the classroom - completion of each activity - discussion in class - presentation
Social competence
K4	be aware of his/her own limitations and need to improve their skills continually			Summarizing methods: Continuous assessment by teachers (observation) Forming methods: - observation of the student's work - discussion in class - opinions of colleagues

ECTS points	1
Student Workload
Form of activity		Number of hours to complete the activity
Classes that require the participation of a teacher:
Realization of the course: lectures (according to the curriculum)		10
Realization of the course: classes (according to the curriculum)		5
Realization of the course: seminars; (according to the curriculum)
Realization of the course: electives
Participation in consultation
		Total hours: 15
Student self-study: 1 punkt ECTS oznacza 25-30 godzin pracy studenta w różnych formach, takich jak np.:
Preparation for the theoretical and practical classes (realization of projects, documentation, case description etc.)		15
Preparation for tests/credits		5
Preparation for an exam/final test-credit		10
		Total hours: 30

Course contents:

Learning outcomes

(symbol and number)

Topics

1. B.W23.; B.W28.; B.W34.; C.W1.; B.U14.;

2. B.W23.; B.W28.; C.W1.; C.W27.;

3. B.W21.; B.W23.;

4. B.W21.; B.W22; C.W1;

5. B.W21.; B.W22.; B.W28; C.W1; B.U14.;

6. B.W21.: B.W22.; B.W34.; C.W19.; C.W26.; B.U14.;

7. C.W26.; C.W27.;

8. B.W21; B.W22; B.W23.; C.W19.; C.W26; C.W27.;

9. B.W34.; B.U14.;

10. B.W21.; B.W22.; B.W23.; B.W28.; C.W1.; C.W26.; C.W27; B.U14.;

11. B.W21.; B.W22.; B.W23.; B.W28.; B.W34.; C.W1.; C.W19.; C.W26.; C.W27.; B.U14., B.U14.;

1. Regenerative medicine – principles and ethics.

2. Progenitor and stem cells – characteristics.

3. Intra- and extracellular matrix.

4. Transcription factors, signaling proteins and cell-surface receptors – principles and functions.

5. Regulation of cells’ differentiation and proliferation.

6. Mechanisms of cell’s death and it’s consequences.

7. Processes which lead to injury of cells and tissues.

8. Healing and regeneration – mechanisms and differences.

9. Principles of carrying out a research.

10. Mechanisms of tissue and organ regeneration;

11. Principles of cell-based and biological therapy.

Obligatory textbook:

Knowledge obtained during the lectures and classes.

Optional textbook:

Anthony Atala, Robert Lanza, James A. Thomson, and Robert M. Nerem; Principles of Regenerative Medicine
Robert A. Brown; Extreme Tissue Engineering

Criteria for assessing the achieved learning outcomes and the form and conditions for receiving credit:

Student obtains a credit on condition that he/she was present on all lectures and classes and obtained a pass from the classes.

Students are obliged to attend all classes. Absences should be excused as soon as possible. In case of illness, a doctor’s leave should be presented; any other absences should be confirmed by the dean or proper authorities. Excused absences should be make up in a fixed time. The consequence of unexcused absences (more than one) is lack for credit at Regenerative medicine.

The conditions of passing the class:

a) performing experiments with showing an understanding of a sense of carried procedures;

b) presentation of the experiment during the last classes

b) credit from a written partial class test.

During the last class every student is obliged to present an evaluation of their experiment, which was carried out on the laboratory classes. Every student may obtain maximum 10 points – 2 points for each of the following: introduction, material and methods, results, conclusion and student’s contribution to the presentation. The minimum 6 points are required to pass the presentation. Passing the presentation is mandatory in order to pass the course of Regenerative Medicine