Research Areas
The Department's scientific focus centers on molecular-genetic analyses pertinent to two primary fields of medicine: oncology and ophthalmology.
In the domain of the molecular-genetic underpinnings of cancer, research investigates various facets to elucidate the mechanisms governing tumor initiation and progression. Gene expression profiles are systematically analyzed across multiple cancer types, including lung, esophageal, colorectal, ovarian, and endometrial cancers.
Additionally, investigations are conducted into the diagnostic and prognostic molecular profiles of non-small cell lung cancer (NSCLC). Particular emphasis is placed on the characterization of mRNA and non-coding RNA (ncRNA) signatures, which may facilitate early detection and differentiation of NSCLC subtypes. Furthermore, the role of lymphangiogenesis markers in esophageal cancer is explored, offering significant insights into the metastatic processes involved.
In the field of ophthalmology, research primarily targets glaucoma, with a specific focus on assessing ncRNA expression. This area of study aims to deepen our understanding of the molecular mechanisms associated with glaucoma, potentially leading to the identification of novel therapeutic targets and enhanced diagnostic methodologies.
The Department engages in comprehensive molecular-genetic analyses employing advanced techniques such as quantitative polymerase chain reaction (qPCR), DNA microarrays, and next-generation sequencing (NGS). These methodologies enable precise analysis of gene expression, simultaneous examination of multiple genes, and, in the case of NGS, comprehensive analysis of the entire genetic material, yielding more robust and accurate molecular data. These tools enhance our understanding of the molecular mechanisms underlying various diseases, constituting a critical component of the Department's research strategy. The outcomes of this research possess significant clinical implications, particularly for diagnostics, prognostic evaluations, and the development of innovative therapeutic interventions.